2-(4-Fluorophenyl)acetohydrazide → HCID 178493105, compound

HRID 1855412Notes

Reaction equation

HRID 1855412 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:16]([NH2:18])=S)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]([NH:29][NH2:30])=O)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]2[NH:18][C:16]([NH:15][C:5]3[CH:6]=[CH:7][C:8]([N:9]4[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]4)=[C:3]([O:2][CH3:1])[CH:4]=3)=[N:30][N:29]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 37716122-(4-Fluorophenyl)acetohydrazideHCID 71650841[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]thiourea

Product 1

HCID 178493105HCID 178493105, compound

Procedure

The title compound was prepared in analogy to example 71c) starting with [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (200 mg, 0.76 mmol) and (4-fluoro-phenyl)-acetic acid hydrazide (141 mg, 0.76 mmol). Obtained as a greyish solid (21 mg, 7%).

Sources & evidence

ORD record
ord-24ac314a1d3844eab96069fca66a33df
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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