4-Fluorobenzohydrazide → HCID 178493102, compound

HRID 1855413Notes

Reaction equation

HRID 1855413 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:15][C:16]([NH2:18])=S)[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.[F:19][C:20]1[CH:29]=[CH:28][C:23]([C:24]([NH:26][NH2:27])=O)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:29]=[CH:28][C:23]([C:24]2[NH:18][C:16]([NH:15][C:5]3[CH:6]=[CH:7][C:8]([N:9]4[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]4)=[C:3]([O:2][CH3:1])[CH:4]=3)=[N:27][N:26]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 99724-FluorobenzohydrazideHCID 71650841[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]thiourea

Product 1

HCID 178493102HCID 178493102, compound

Procedure

The title compound was prepared in analogy to example 71c) starting with [3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-thiourea (250 mg, 0.95 mmol) and 4-fluoro-benzohydrazide (162 mg, 0.95 mmol). Obtained as a brownish solid (41 mg, 12%).

Sources & evidence

ORD record
ord-f4dd16785ca346b5807d61ffa01cadb4
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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