p-(Trifluoromethoxy)phenol → HCID 86633622, compound

HRID 1855424Notes

Reaction equation

HRID 1855424 reaction equation
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[Cl:13][C:14]1[N:19]=[C:18](Cl)[CH:17]=[C:16]([CH3:21])[N:15]=1>>[Cl:13][C:14]1[N:15]=[C:16]([CH3:21])[CH:17]=[C:18]([O:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:11])([F:12])[F:1])=[CH:9][CH:8]=2)[N:19]=1

Participants

3

Reactant 2

HCID 70015p-(Trifluoromethoxy)phenolHCID 794712,4-Dichloro-6-methylpyrimidine

Product 1

HCID 86633622HCID 86633622, compoundYield 60%

Procedure

Prepared in analogy to example 81a) from 4-trifluoromethoxyphenol and 2,4-dichloro-6-methylpyrimidine in a yield of 60%. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.28 (d, 2H), 7.18 (d, 2H), 6.65 (s, 1H), 2.50 (s, 3H).

Sources & evidence

ORD record
ord-2d471607ff684af8b2f07484e9c30098
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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