Ethanol → HCID 87523410, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 2,4-dichloropyrimidine-6-carboxylate (2.07 g, 10.0 mmol) and potassium tert.-butoxide (1.12 g, 10.0 mmol) in ethanol (50 mL) was stirred for 4 h at 60° C. The mixture was cooled to, insoluble material was removed by filtration, and the filtrate was evaporated under reduced pressure. The oily residue was partitioned between ethyl acetate and brine, and the organic layer was dried over sodium sulfate and evaporated under reduced pressure to give crude title compound (0.98 g, 43%) as colorless oil. MS ISP (m/e): 231.1 [(M+H)+].

Provenance & Evidence