2-(Methylamino)ethanol → 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine

HRID 1855454ノート

反応式

HRID 1855454 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][NH:11][CH2:12][CH2:13][OH:14]>>[Cl:1][C:2]1[N:7]=[C:6]([N:11]([CH3:10])[CH2:12][CH2:13][OH:14])[CH:5]=[C:4]([CH3:9])[N:3]=1

参加物

3

反応物 2

HCID 80162-(Methylamino)ethanolHCID 794712,4-Dichloro-6-methylpyrimidine

生成物 1

HCID 183238282-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine収率 61%

実験手順

Prepared in analogy to example 98a), using 2,4-dichloro-6-methylpyrimidine and 2-(methylamino)ethanol. The title compound was isolated as a yellowish oil in a yield of 61%. MS ISP (m/e): 202.2 (100) [(M+H)+]. 1H NMR (CDCl3, 300 MHz): δ (ppm)=6.22 (s, 1H), 3.86 (t, 2H), 3.70-3.60 (m, 2H), 3.11 (s, 3H), 2.70 (s very broad, 1H), 2.34 (s, 3H).

後処理

  1. customPrepared in analogy to example 98a),

出典と根拠

ORDレコード
ord-979726c0701c407fbde1f557ce426b47
出典データセット
uspto-grants-2015_02
特許番号
US08962834B2

反応ノート

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