4-(Trifluoromethoxy)aniline → HCID 44192798, compound

HRID 1855476Notes

Reaction equation

HRID 1855476 reaction equation
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1.Cl[C:14]1[N:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]3)=[C:23]([O:33][CH3:34])[CH:22]=2)[CH:17]=[CH:16][CH:15]=1>>[CH3:34][O:33][C:23]1[CH:22]=[C:21]([NH:20][C:18]2[CH:17]=[CH:16][CH:15]=[C:14]([NH:8][C:7]3[CH:9]=[CH:10][C:4]([O:3][C:2]([F:11])([F:12])[F:1])=[CH:5][CH:6]=3)[N:19]=2)[CH:26]=[CH:25][C:24]=1[N:27]1[CH:31]=[C:30]([CH3:32])[N:29]=[CH:28]1

Participants

3

Reactant 2

HCID 6008484-(Trifluoromethoxy)anilineHCID 86633629HCID 86633629, compound

Product 1

HCID 44192798HCID 44192798, compound

Procedure

Prepared in analogy to example 62 from 4-(trifluoromethoxy)aniline and (6-chloro-pyridin-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine. The title compound was obtained as a brownish solid (Yield=10%). MS ISP (m/e): 456.3 (100) [(M+H)+].

Sources & evidence

ORD record
ord-2ba4f967308244a0a8a4361f2df7a62c
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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