2,6-Dichloro-4-(trifluoromethyl)pyridine → HCID 86633630, compound

HRID 1855483Notes

Reaction equation

HRID 1855483 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.[Cl:16][C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19](Cl)[N:18]=1>>[Cl:16][C:17]1[N:18]=[C:19]([NH:15][C:5]2[CH:6]=[CH:7][C:8]([N:9]3[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]3)=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:20]=[C:21]([C:23]([F:26])([F:24])[F:25])[CH:22]=1

Participants

3

Reactant 2

HCID 5209682,6-Dichloro-4-(trifluoromethyl)pyridineHCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

Product 1

HCID 86633630HCID 86633630, compound

Procedure

Prepared in analogy to example 62 from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 2,6-dichloro-4-trifluoromethyl-pyridine. The title compound was obtained as a yellowish solid (Yield=30%). MS ISP (m/e): 383.1 (39) [(M+H)+]. 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.67 (d, 1H), 7.39 (d, 1H), 7.23 (d, 1H), 7.11 (s, 1H), 6.99 (s, 1H), 6.965-6.85 (m, 3H), 3.87 (s, 3H), 2.31 (s, 3H).

Sources & evidence

ORD record
ord-8279111abc154057b40618e13f9ad4f9
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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