3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline → HCID 131732516, compound

HRID 1855489Notes

Reaction equation

HRID 1855489 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:15])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]1.[C:16]([SiH2:20][O:21][C:22]([CH3:32])([CH3:31])[C:23]1[CH:28]=[C:27](Cl)[N:26]=[C:25]([Cl:30])[CH:24]=1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([SiH2:20][O:21][C:22]([CH3:32])([CH3:31])[C:23]1[CH:24]=[C:25]([Cl:30])[N:26]=[C:27]([NH:15][C:5]2[CH:6]=[CH:7][C:8]([N:9]3[CH:13]=[C:12]([CH3:14])[N:11]=[CH:10]3)=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:28]=1)([CH3:19])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 454801813-methoxy-4-(4-methyl-1H-imidazol-1-yl)anilineHCID 131732517HCID 131732517, compound

Product 1

HCID 131732516HCID 131732516, compound

Procedure

Prepared in analogy to example 62 from 3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamine and 4-(tert-butyl-dimethyl-silanyloxymethyl)-2,6-dichloro-pyridine. The title compound was obtained as a yellowish solid (Yield=31%). 1H NMR (CDCl3, 300 MHz): δ (ppm)=7.64 (s, 1H), 7.36 (d, 1H), 7.17 (d, 1H), 6.95-6.85 (m, 2H), 6.75 (s, 1H), 6.73 (s, 1H), 6.68 (s broad, 1H), 4.65 (s, 2H), 3.86 (s, 3H), 2.30 (s, 3H), 0.94 (s, 9H), 0.11 (s, 6H).

Sources & evidence

ORD record
ord-102b5a16ff9f4244b0485857b846d556
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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