4-(Trifluoromethoxy)aniline → HCID 131732518, compound

HRID 1855490Notes

Reaction equation

HRID 1855490 reaction equation
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1.[C:13]([SiH2:17][O:18][C:19]([CH3:43])([CH3:42])[C:20]1[CH:25]=[C:24](Cl)[N:23]=[C:22]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH:38]=[C:37]([CH3:39])[N:36]=[CH:35]3)=[C:30]([O:40][CH3:41])[CH:29]=2)[CH:21]=1)([CH3:16])([CH3:15])[CH3:14]>>[C:13]([SiH2:17][O:18][C:19]([CH3:43])([CH3:42])[C:20]1[CH:25]=[C:24]([NH:8][C:7]2[CH:9]=[CH:10][C:4]([O:3][C:2]([F:11])([F:12])[F:1])=[CH:5][CH:6]=2)[N:23]=[C:22]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH:38]=[C:37]([CH3:39])[N:36]=[CH:35]3)=[C:30]([O:40][CH3:41])[CH:29]=2)[CH:21]=1)([CH3:16])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 6008484-(Trifluoromethoxy)anilineHCID 131732516HCID 131732516, compound

Product 1

HCID 131732518HCID 131732518, compound

Procedure

Prepared in analogy to example 62 from 4-(trifluoromethoxy)aniline and [4-(tert-butyl-dimethyl-silanyloxymethyl)-6-chloro-pyridin-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine. The title compound was obtained as a brownish gum (Yield=56%).

Sources & evidence

ORD record
ord-10f5de442a1c4508a0b2dbec649629e4
Source dataset
uspto-grants-2015_02
Patent number
US08962834B2

Reaction notes

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