3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)aniline → HCID 57829791, compound

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Reaction Steps

The title compound was prepared from 4-benzyl-2-chloro-6-methyl-pyrimidine (86 mg, 0.54 mmol) and 3-fluoro-4-(5-methyl-[1,2,4]triazol-1-yl)-phenylamine (75 mg, 0.39 mmol) using in analogous manner the procedure described in example 206c). Column chromatography (15 g silica, dichloromethane+3.5% methanol v/v) afforded the title compound as a light yellow waxy solid (100 mg, 68%). 1H NMR (CDCl3, 300 MHz): δ (ppm)=8.07 (dd, 1H), 7.97 (s, 1H), 7.27 (m, 7H), 6.56 (s, 1H), 4.00 (s, 2H), 2.42 (d, 3H), 2.39 (s, 3H). MS ISP (m/e): 375.2 [(M+H)+].

Provenance & Evidence