4-(2-Methyl-1,3-oxazol-5-yl)aniline → 2-{6-(4-Chloro-phenyl)-2-[4-(2-methyl-oxazol-5-yl)-phenylamino]-pyrimidin-4-yl}-propan-2-ol

Participants

Reaction Steps

Using in analogous manner the procedure described in example 1e), 2-[2-chloro-6-(4-chloro-phenyl)-pyrimidin-4-yl]-propan-2-ol (112 mg, 0.3 mmol) was reacted with 4-(2-methyl-oxazol-5-yl)-phenylamine (61 mg, 0.3 mmol) to give the title compound as light yellow solid (28 mg, 22%). MS ISP (m/e): 421.1 [(M+H)+]. 1H NMR (CDCl3, 300 MHz): δ (ppm)=8.04, 7.74, 7.63 and 7.50 (4 d, 4×2H), 7.20 (s, 1H), 7.23 (s, 1H), 7.15 (s, 1H), 4.01 (s, 1H), 2.53 (s, 3H), 1.61 (s, 6H).

Provenance & Evidence