Cesium carbonate → HCID 58122461, compound

Participants

Reaction Steps

A mixture of 2-chloro-5-nitro-toluene (2.0 g, 12 mmol), of 4-methylimidazole (1.0 g, 12 mmol) and of cesium carbonate (5.7 g, 17.5 mmol) in acetonitrile (20 mL) was refluxed for 15 h. The reaction mixture was cooled, quenched by addition of water and extracted with ethyl acetate. The organic layer was dried over sodium sulfate and evaporated under reduced pressure and the crude material was purified by column chromatography on silica gel using ethyl acetate as eluent to yield the title compound (1.27 g, 50%) as a slightly brownish solid. MS ISP (m/e): 218.3 (100) [(M+H)+].

Provenance & Evidence