HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → N-tert-butylisobutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | N-tert-Butylpivalamide | HCID 299326 | — |
| Product | N-tert-butylisobutyramide | HCID 344892 | 96% |
Reaction Steps
In a fashion similar to the preparation of LtBu,tBuH, treatment of tert-butylamine (11.3 mL, 105 mmol) and triethylamine (14.9 mL, 105 mmol) with isobutyryl chloride (10.8 mL, 100 mmol) afforded LiPr,tBuH as white crystalline solid (13.75 g, 96%) upon sublimation at 55° C./0.05 Torr: mp 117-119° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962876B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-3ae2ff0ca1264e9284ebdc3f6d5e9051 |
| Source note | uspto-grants-2015_02 |