HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → N-Isopropylisobutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | N-tert-Butylpivalamide | HCID 299326 | — |
| Product | N-Isopropylisobutyramide | HCID 230354 | 94% |
Reaction Steps
In a fashion similar to the preparation of LtBu,tBuH, treatment of isopropylamine (9.0 mL, 105 mmol) and triethylamine (14.9 mL, 105 mmol) with isobutyryl chloride (10.8 mL, 100 mmol) afforded LiPr,iPrH as white crystalline solid (12.14 g, 94%) upon sublimation at 55° C./0.05 Torr: mp 104-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962876B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-adb50df66f5f4401908e751f353a65f6 |
| Source note | uspto-grants-2015_02 |