HCID 66992743, compound → HCID 66992953, compound

Participants

Reaction Steps

785 mg (1.5 mmol) of 2-[5-(1-trityl-1H-imidazol-4-yl)pent-4-enyl]isoindole-1,3-dione, 10 ml of a MeOH/THF mixture (6/4) and 392 mg of 10% Pd/C are introduced into a Parr bomb. The reaction medium is stirred at room temperature under a hydrogen pressure of 5 bar. After 4 hours, the reaction medium is filtered through Celite and concentrated. The crude product obtained is chromatographed on silica gel (eluent: heptane/EtOAc (5/5) and then CH2Cl2/MeOH (9/1)). 380 mg of 2-[5-(1-trityl-1H-imidazol-4-yl)pentyl]isoindole-1,3-dione in the form of a white powder are obtained in a yield of 48%.

Provenance & Evidence