HCID 131711840, compound → HCID 15600051, compound

HRID 1855750Notes

Reaction equation

HRID 1855750 reaction equation
C(OC([NH:11][C@H:12]([C:15]([NH:17][C@H:18]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16])[CH2:13][OH:14])=O)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:11][C@H:12]([C:15]([NH:17][C@H:18]([C:23]([O:25][C:26]([CH3:28])([CH3:27])[CH3:29])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16])[CH2:13][OH:14]

Participants

4

Reactant 1

HCID 131711840HCID 131711840, compound

Product 1

HCID 15600051HCID 15600051, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of Z-Ser-Leu-OBut (11.36 g, 27.8 mmol, described in Example 3) and 5% palladium on carbon (1.1 g) in glacial acetic acid is subjected to hydrogenation. The mixture is filtered and the filtrate is evaporated under reduced pressure to give H-Ser-Leu-OBut in the form of its acetate salt. This product is suspended in toluene and the toluene is removed by distillation so that excess acetic acid is removed azeotropically.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-896e6f98c9e24b61b6f61bdf6c0a046b
Source dataset
uspto-grants-1980_08
Patent number
US04216209

Reaction notes

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