Benzyloxycarbonyl-prolyl-histidyl-leucine, tert-Butyl Ester → HCID 178445971, compound

Participants

Reaction Steps

A mixture of the protected tripeptide of formula III, Z-Pro-His-Leu-OBut (5.9 g, 10.6 mmol, described in Example 2), and 5% palladium on carbon (600 mg) in glacial acetic acid is subjected to hydrogenation. The mixture is filtered and the filtrate evaporated under reduced pressure to give 5.2 g of H-Pro-His-Leu-OBut in the form of its acetate salt. This product is suspended in toluene and the toluene then is removed by distillation so the excess acetic acid is removed azeotropically.

Provenance & Evidence