Sodium Hydroxide → HCID 23348588, compound

HRID 1855778Notes

Reaction equation

HRID 1855778 reaction equation
[OH-].[Na+].[CH3:3][CH:4]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:5]#[N:6]>[Ni].CO>[NH2:6][CH2:5][CH:4]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[CH3:3]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 14418021HCID 14418021, compound

Product 1

HCID 23348588HCID 23348588, compoundYield 69.1%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

0.1 g of sodium hydroxide and 1 g of Raney nickel are added to a solution of 13 g (0.094 mole) of alpha-methyl-2-oxo-1-pyrrolidineacetonitrile in 250 ml of methanol and hydrogenated at ambient temperature and pressure until there is no further absorption of hydrogen. The catalyst is then filtered off through a Hyflo-cel filter and the filtrate is evaporated under reduced pressure. 9.2 g (0.065 mole) of 1-(2-amino-1-methylethyl)-2-pyrrolidinone are obtained, this product being used as it is for continuing the synthesis (Yield: 69% of theory). I.R. spectrum (film) in cm-1 : 3380, 2970, 2930, 2870, 1670, 1290.

Workup

  1. customno further absorption of hydrogen
  2. filtrationThe catalyst is then filtered off through a Hyflo-cel
  3. filtrationfilter
  4. customthe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-2571fda8d48b4499a6499393dd613c84
Source dataset
uspto-grants-1980_08
Patent number
US04216221

Reaction notes

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