1,1'-Carbonyldiimidazole → HCID 23348591, compound

Participants

Reaction Steps

A solution of 8.1 g (0.05 mole) of 1,1'-carbonyldiimidazole in 20 ml of methylene chloride is added, with vigorous stirring, to a solution of 5.7 g (0.05 mole) of 1-aminomethyl-2-pyrrolidinone in 20 ml of methylene chloride cooled to -70° C., whereafter 8.5 g (0.05 mole) of 1-aminomethyloctahydro-2H-azonin-2-one in 20 ml of methylene chloride are also added. After the addition, the reaction mixture is heated under reflux for 2 hours. After evaporation of the solvent under reduced pressure, the residue obtained is purified by chromatography on silica (eluent: chloroform). 5.7 g (0.0184 mole) of 1-[(octahydro-2-oxo-1H-azonin-1-yl)methyl]-3-[(2-oxopyrrolidino)methyl]-urea are thus obtained.

Provenance & Evidence