HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1855809Generated: October 26, 2026
Methanol, 1,1-diethoxy-, 1-acetate → alpha-Carbethoxy-alpha-diethoxymethyl-beta-(3,4-dimethoxyphenyl)propionitrile
https://huagongshe.com/reaction/1855809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol, 1,1-diethoxy-, 1-acetate | HCID 84166 | — |
| Reactant | Ethyl 2-cyano-3-(3,4-dimethoxyphenyl)propanoate | HCID 12254388 | — |
| Product | alpha-Carbethoxy-alpha-diethoxymethyl-beta-(3,4-dimethoxyphenyl)propionitrile | HCID 12559142 | — |
Reaction Steps
A mixture of α-Carbethoxy-β-[3,4-dimethoxyphenyl]propionitrile (10 g) and diethoxymethyl acetate (30 g) was heated at 95° C. for 20 hours. The volatiles were removed under vacuum pump pressure leaving 13.4 g (94%) of a nearly colorless oil which solidified on standing at -5° C. to a white solid, m.p. 62°-65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04216319 |
|---|
| Source dataset | uspto-grants-1980_08 |
|---|
| ORD ID | ord-56fd5d77faf84b7f965a6b38bd17742b |
|---|
| Source note | uspto-grants-1980_08 |
|---|
