反应详情

A solution of α-carbethoxy-α-diethoxymethyl-β-(3,4-dimethoxyphenyl)propionitrile (3.75 g) and an equivalent amount of potassium hydroxide in ethanol (70 ml) was heated at reflux for one hour. A solution of guanidine (0.035 mol) in ethanol (50 ml) was added and reflux was resumed. Ethanol was boiled off until the reaction temperature reached 85° C. After 17 hours at reflux the mixture was allowed to cool and the product was filtered and washed with ethanol giving a white solid which was purified as described in Example 5 to yield 1.4 g (54%) of the title compound, m.p. 231°-233° C.

1. temperatureat reflux for one hour
2. temperaturereflux
3. customreached 85° C
4. temperatureAfter 17 hours at reflux the mixture
5. temperatureto cool
6. filtrationthe product was filtered
7. washwashed with ethanol giving a white solid which
8. customwas purified