2-[(2-Butoxyphenoxy)methyl]oxirane → HCID 23349132, compound

Participants

Reaction Steps

4.5 g of 2-n-butoxyphenyl glycidyl ether ##STR27## are heated under reflux together with 5.8 g of N-benzyl-N'-[1,3-dimethyl-2,4-dioxopyrimid-6-yl]ethylenediamine ##STR28## (in 150 ml of ethanol) for 2 hours. The resulting solution is then cooled and concentrated in vacuo. A resinous residue remains. This residue is dissolved in 150 ml of dioxane (without further purification) and then hydrogenated with H2 in the presence of Pd/C at 20° C. for 10 hours. The catalyst is then filtered of; the filtrate is concentrated; and the residue is recrystallized once from toluene. N-[3-(o-Butoxyphenoxy)-2-hydroxypropyl]-N'-[1,3-dimethyl-2,4-dioxopyrimid-6-yl]ethylenediamine of the formula ##STR29## is thus obtained.

Provenance & Evidence