(+-)-Tetramisole → Levamisole

Participants

Reaction Steps

The utility of the compound of this invention: chiral-2,3-Bis(diphenylphosphinomethyl)bicyclo[2.2.1]heptane is as an intermediate in the manufacture of a chiral rhodium-diphosphine catalyst which is useful in the reduction of a tetramisole precursor to give a significant excess of the desired S-(-) isomer, levamisole. The chiral rhodium-diphosphine catalyst and the process of using the catalyst in the reduction of the tetramisole precursor is also novel.

Provenance & Evidence