2-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amine → 2-[2-(3-Bromo-2-pyridylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone

Participants

Reaction Steps

5-(4-Pyridylmethyl)-2-methylthio-4-pyrimidone (1.1 g) was reacted with 2-(3-bromo-2-pyridylmethylthio)ethylamine (1.15 g) according to the procedure of Example 2. The reaction mixture was triturated under hot water to give 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone. This product was acidified with dilute ethanolic hydrogen chloride, evaporated to dryness and the residue recrystallised from ethanol to give the title compound m.p. 211°-215° (decomp). (Found: C, 42.65; H, 3.9; N, 13.9; S, 6.3; C18H18Br N5OS.2HCl requires: C, 42.8; H, 4.0; N, 13.9; S, 6.35%)

Provenance & Evidence