4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → HCID 3054539, compound

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An intimate mixture of 5-(2-thienylmethyl)-2-methylthio-4-pyrimidone (1.43 g) and 2-(5-methyl-4-imidazolylmethylthio)ethylamine (1.03 g) was heated at 140° for 6 hours. The cooled residue was washed with water to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-thienylmethyl)-4-pyrimidone, and this product was treated with dilute ethanolic HCl to give the title compound in 40% yield, m.p. 172°-176° (ethanol-acetonitrile). The dihydrochloride was passed down an ion-exchange column of IRA 400 eluting with 1 N hydrobromic acid, and the eluate was evaporated to dryness and recrystallised from ethanol acetonitrile to give the corresponding dihydrobromide m.p. 99°-203°. (Found: C, 36.7; H, 4.2; N, 13.5; S, 12.1; Br, 30.6; C16H19N5OS2.2HBr Requires: C, 36.7; H, 4.0; N, 13.4; S, 12.2; Br, 30.5%)

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