4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → HCID 3048908, compound

HRID 1855844Notes

Reaction equation

HRID 1855844 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[C:9](=[O:16])[NH:10][C:11](SC)=[N:12][CH:13]=2)[CH:2]=1.[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][NH2:27]>>[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][NH:27][C:11]1[NH:10][C:9](=[O:16])[C:8]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[CH:13][N:12]=1

Participants

3

Reactant 2

HCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 127838233-Pyridylmethyl-2-methylthio-4-pyrimidone

Product 1

HCID 3048908HCID 3048908, compound

Procedure

An intimate mixture of 5-(3-pyridylmethyl)-2-methylthio-4-pyrimidone (6.55 g) and 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (4.8 g) was heated at 130°-135° for 7 hours. The cool mixture was triturated with hot water to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone and this product was treated with dilute ethanolic HCl to give the title compound m.p. 237°-241° (ethanol-water) (Found: C, 43.7; H, 5.2; N, 17.4; S, 6.5; Cl--22.0. C17H20N6OS.3HCl requires C, 43.8; H, 5.0; N, 18.0; S, 6.9; Cl, 22.8%)

Workup

  1. temperaturewas heated at 130°-135° for 7 hours
  2. customThe cool mixture was triturated with hot water

Sources & evidence

ORD record
ord-2c055a73fff24ddea39bcf5f3732f4ae
Source dataset
uspto-grants-1980_08
Patent number
US04216318

Reaction notes

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