反应详情

An intimate mixture of 5-(3-pyridylmethyl)-2-methylthio-4-pyrimidone (6.55 g) and 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (4.8 g) was heated at 130°-135° for 7 hours. The cool mixture was triturated with hot water to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone and this product was treated with dilute ethanolic HCl to give the title compound m.p. 237°-241° (ethanol-water) (Found: C, 43.7; H, 5.2; N, 17.4; S, 6.5; Cl--22.0. C17H20N6OS.3HCl requires C, 43.8; H, 5.0; N, 18.0; S, 6.9; Cl, 22.8%)

1. temperaturewas heated at 130°-135° for 7 hours
2. customThe cool mixture was triturated with hot water