HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridylmethyl-2-methylthio-4-pyrimidone → 2-[2-(3-Bromo-2-pyridylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridylmethyl-2-methylthio-4-pyrimidone | HCID 12783823 | — |
| Reactant | 2-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amine | HCID 12951527 | — |
| Product | 2-[2-(3-Bromo-2-pyridylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone | HCID 3048914 | — |
Reaction Steps
5-(3-Pyridylmethyl)-2-methylthio-4-pyrimidone (1.27 g) was reacted with 2-(3-bromo-2-pyridylmethylthio)-ethylamine (1.35 g) according to the procedure in Example 2. The reaction mixture was triturated with hot water to give 2-[2-(3-bromo-2-pyridylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone, and this product was treated with dilute hydrobromic acid to give the title compound, m.p. 217°-220.5° (ex-methanol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04216318 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-bf3eeb3c32bc466d857c8a9bd2917437 |
| Source note | uspto-grants-1980_08 |