反应详情

A mixture of benzene (20 ml), diphenyl phosphite (5.62 g, 24 mmole), imidazole (2.45 g, 36 mmole) and o-chlorophenyldiphenylmethanol (2.95 g, 10 mmole) obtained in Example 1 (A) was refluxed for 8 hours. After cooling, the reaction mixture was washed with a 5% aqueous potassium hydroxide solution (20 ml). The benzene layer was separated, washed with water, dried over magnesium sulfate and evaporated. Recrystallization of the crystalline residue from acetonitrile gave 2.51 g of 1-(o-chlorophenyldiphenylmethyl)imidazole. Yield, 73%. M.P., 142°-143° C.

1. temperaturewas refluxed for 8 hours
2. temperatureAfter cooling
3. washthe reaction mixture was washed with a 5% aqueous potassium hydroxide solution (20 ml)
4. customThe benzene layer was separated
5. washwashed with water
6. dry with materialdried over magnesium sulfate
7. customevaporated
8. customRecrystallization of the crystalline residue from acetonitrile