反应详情

A mixture of toluene (20 ml), diphenyl phosphite (2.07 g, 6.7 mmole), imidazole (1.09 g, 16 mmole) and o-chlorophenyldiphenylmethanol (2.95 g, 10 mmole) obtained in Example 1 (A) was refluxed for 4 hours. After cooling to room temperature, the reaction mixture was washed with a 5% aqueous potassium hydroxide solution (20 ml). The toluene layer was separated, washed with water, dried and evaporated to give a crystalline mass. Recrystallization from acetonitrile gave 2.57 g of 1-(o-chlorophenyldiphenylmethyl)imidazole. Yield, 74.5%. M.P., 142°-143° C.

1. temperaturewas refluxed for 4 hours
2. washthe reaction mixture was washed with a 5% aqueous potassium hydroxide solution (20 ml)
3. customThe toluene layer was separated
4. washwashed with water
5. customdried
6. customevaporated
7. customto give a crystalline mass
8. customRecrystallization from acetonitrile