Imidazole → Clotrimazole

Participants

Reaction Steps

A mixture of methyl isobutyl ketone (150 ml), diphenyl phosphite (32.8 g), imidazole (13.6 g) and o-chlorophenyldiphenylmethanol (29.5 g) obtained in Example 1 (A) was refluxed for 4 hours. A 10% aqueous sodium hydroxide solution (250 ml) was added thereto and the resultant mixture was refluxed for 1 hour. After cooling to room temperature, the organic layer was separated, washed with water, and evaporated to give a crystalline mass. Recrystallization from methyl isobutyl ketone gave 26.5 g of 1-(o-chlorophenyldiphenylmethyl)imidazole. Yield, 77%. M.P., 142°-143° C.

Provenance & Evidence