Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Triphenyl phosphite | HCID 7540 | — |
| Reactant | (2-Chlorophenyl)diphenylmethanol | HCID 298659 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | Clotrimazole | HCID 2812 | 77.9% |
Reaction Steps
A mixture of methyl isobutyl ketone (150 ml), triphenyl phosphite (24.8 g), imidazole (10.9 g) and o-chlorophenyldiphenylmethanol (29.5 g) obtained in Example 1 (A) was heated at 100° C. for 5 hours. The reaction mixture was treated in the same manner as in Example 4 to give 26.9 g of 1-(o-chlorophenyldiphenylmethyl)imidazole. Yield, 78%. M.P., 143°-144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04216333 |
|---|
| Source dataset | uspto-grants-1980_08 |
|---|
| ORD ID | ord-690f7e33883445efac5801c6eed20d13 |
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| Source note | uspto-grants-1980_08 |
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