HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Clotrimazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | (2-Chlorophenyl)diphenylmethanol | HCID 298659 | — |
| Reactant | Diphenoxyphosphanolate | HCID 23418553 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Clotrimazole | HCID 2812 | 78.2% |
Reaction Steps
A mixture of pyridine (15 ml), diphenyl phosphite (2.34 g), imidazole (0.68 g) and o-chlorophenyldiphenylmethanol (2.36 g) obtained in Example 1 (B) was refluxed for 3 hours. The reaction mixture was treated in the same manner as in Example 1 (C) to give 2.16 g of 1-(o-chlorophenyldiphenylmethyl)imidazole. Yield, 78.3%. M.P., 142°-143° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04216333 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-d7b710eef47940b7b5c8fdb9dfb8015c |
| Source note | uspto-grants-1980_08 |