HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Clotrimazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | (2-Chlorophenyl)diphenylmethanol | HCID 298659 | — |
| Reactant | Diphenoxyphosphanolate | HCID 23418553 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Clotrimazole | HCID 2812 | 78.9% |
Reaction Steps
A mixture of benzene (20 ml), diphenyl phosphite (5.62 g, 24 mmole), imidazole (2.45 g, 36 mmole) and o-chlorophenyldiphenylmethanol (2.95 g, 10 mmole) obtained in Example 1 (B) was refluxed for 8 hours. The reaction mixture was treated in the same manner as in Example 2 to give 2.72 g of 1-(o-chlorophenyldiphenylmethyl)imidazole. Yield, 79%. M.P., 143°-144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04216333 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-ac921daf6eae4adab7e4a6dd17fcdd90 |
| Source note | uspto-grants-1980_08 |