HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Clotrimazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Triphenyl phosphite | HCID 7540 | — |
| Reactant | (2-Chlorophenyl)diphenylmethanol | HCID 298659 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Clotrimazole | HCID 2812 | 81.2% |
Reaction Steps
A mixture of toluene (20 ml), triphenyl phosphite (2.07 g, 6.7 mmole), imidazole (1.09 g, 16 mmole) and o-chlorophenyldiphenylmethanol (2.95 g, 10 mmole) obtained in Example 1 (B) was refluxed for 4 hours. The reaction mixture was treated in the same manner as in Example 3 to give 2.80 g of 1-(o-chlorophenyldiphenylmethyl)imidazole. Yield, 81%. M.P., 142°-143° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04216333 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-31a2c723676a433aa00f0e259134e0ae |
| Source note | uspto-grants-1980_08 |