HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Dechloroclotrimazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Triphenylcarbinol | HCID 6457 | — |
| Reactant | Triphenyl phosphite | HCID 7540 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Dechloroclotrimazole | HCID 618231 | 82.6% |
Reaction Steps
A mixture of pyridine (15 ml), triphenyl phosphite (1.55 g, 5 mmole), imidazole (0.68 g, 10 mmole) and triphenylmethanol (2.08 g, 8 mmole) was refluxed for 3 hours. The reaction mixture was treated in the same manner as in Example 11 to give 2.05 g of 1-triphenylmethylimidazole as colorless needles. Yield, 82.7%. M.P., 218°-221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04216333 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-4b96f5c019ad47828eefbf6c0445312a |
| Source note | uspto-grants-1980_08 |