1-(2-Chloroethyl)-2-methylpiperidine → alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2-methyl-1-piperidinyl)ethyl]acetonitrile
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:9]#[N:10].Cl[CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]1[CH3:29]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:15])[CH3:16])([CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]1[CH3:29])[C:9]#[N:10]Participants
3
Procedure
Substitution of equivalent quantities of α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]acetonitrile and 1-(2-chloroethyl)-2-methylpiperidine in the procedure of Example 2, Method B and substantial repetition of the procedure detailed therein, affords α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-[2-(2-methyl-1-piperidinyl)ethyl]acetonitrile, as an oil boiling at about 170°-175° C. at 0.5 mm. pressure.
Sources & evidence
- ORD record
- ord-f6405be84cd74ea3a86858b0fbd0063d
- Source dataset
- uspto-grants-1980_08
- Patent number
- US04217306
Reaction notes
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