1-(2-Chloroethyl)-2,6-dimethylpiperidine → alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2,6-dimethyl-1-piperidinyl)ethyl]acetonitrile

Participants

Reaction Steps

Substitution of equivalent quantities of α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]acetonitrile and 1-(2-chloroethyl)-2,6-dimethylpiperidine in the procedure of Example 2, Method B, and substantial repetition of the procedure detailed therein, affords α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-[2-(2,6-dimethyl-1-piperidinyl)ethyl]acetonitrile, as an oil boiling at about 170°-175° C. at 0.3 mm. pressure.

Provenance & Evidence