HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 131711850, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N,N-Dimethylaniline | HCID 949 | — |
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 2-Methyl 1-(phenylmethyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate | HCID 688411 | — |
| Reactant | HCID 131711851 | HCID 131711851 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 131711850 | HCID 131711850 | — |
Reaction Steps
A solution of equivalent quantities of N-carbobenzyloxy-trans-4-hydroxy-L-proline, methyl ester from Example 1, part b, and dimethylaniline is treated with a solution of phosgene in toluene. After standing overnight an equivalent quantity of ammonia is passed through the solution of trans-N-carbobenzyloxy-4-[(chlorocarbonyl)oxy]-L-proline, methyl ester. After standing for twelve hours at room temperature, the solution is washed with water, dried over magnesium sulfate, filtered and the solvent evaporated to give trans-N-carbobenzyloxy-4-[(aminocarbonyl)oxy]-L-proline, methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04217359 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-f200641de1f740d3b594bd7ca1beb1fb |
| Source note | uspto-grants-1980_08 |