Potassium Hydroxide → HCID 13491773, compound

HRID 1856016Notes

Reaction equation

HRID 1856016 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][OH:10])[C:5]([CH:11](Br)[CH2:12]Br)=[CH:4][N:3]=1.[OH-].[K+]>>[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][OH:10])[C:5]([C:11]#[CH:12])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 20264040HCID 20264040, compound

Product 1

HCID 13491773HCID 13491773, compound

Procedure

The oily product from Step A was refluxed in 15 ml. of 10% (w/v) ethanolic potassium hydroxide under nitrogen for 10 minutes. After cooling the solvent was evaporated. The residue was extracted with 2×20 ml. of hot isopropanol which was then filtered and evaporated to give solid 2-methyl-3-hydroxy-4-hydroxymethyl-5-ethynylpyridine, m.p. 170°-171° C.

Workup

  1. temperatureAfter cooling the solvent
  2. customwas evaporated
  3. extractionThe residue was extracted with 2×20 ml
  4. filtrationof hot isopropanol which was then filtered
  5. customevaporated

Sources & evidence

ORD record
ord-c1c53ee40aab483ab09344f5d5895a33
Source dataset
uspto-grants-1980_08
Patent number
US04217352

Reaction notes

Loading…