Acetic Anhydride → 2,5-Di(acetoxymethyl)pyridine

HRID 1856036Notes

Reaction equation

HRID 1856036 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10](=[O:12])[CH3:11])=[CH:4][N+:3]=1[O-].[C:14]([O:17]C(=O)C)(=[O:16])[CH3:15]>>[C:14]([O:17][CH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10](=[O:12])[CH3:11])=[CH:4][N:3]=1)(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 202639702-methyl-5-acetoxymethylpyridine-N-oxide

Product 1

HCID 202639862,5-Di(acetoxymethyl)pyridine

Procedure

2-Methyl-5-acetoxymethylpyridine-N-oxide (0.05 mole) is refluxed in 50 ml. of acetic anhydride for two hours and then evaporated to dryness. The residue is fractionally distilled under high vacuum to obtain 2,5-di(acetoxymethyl)pyridine.

Workup

  1. customevaporated to dryness
  2. distillationThe residue is fractionally distilled under high vacuum

Sources & evidence

ORD record
ord-e3cc7471bba04c97aa00d956c98cd889
Source dataset
uspto-grants-1980_08
Patent number
US04217352

Reaction notes

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