反应详情

温度

80 °C

A suspension of rhodium acetate (2 mg) and 3-azido-4-(3-benzyloxycarbonyl-3-diazo-2-oxopropyl)-azetidin-2-one (1 mmol) in anhydrous benzene (20 ml) is deoxygenated by bubbling nitrogen through it for 15 mins. The suspension is then stirred with heating in an oil bath at 80° C. for 30 min. After cooling to room temperature, the mixture is filtered and the filtrate is evaporated under vacuum to provide benzyl 6-azido-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylate.

1. customis deoxygenated
2. customby bubbling nitrogen through it for 15 mins
3. temperatureAfter cooling to room temperature
4. filtrationthe mixture is filtered
5. customthe filtrate is evaporated under vacuum