HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester → 1-(3-acetylthio-1-oxopropyl)-4,5-dihydro-4-hydroxy-1H-pyrrole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester | HCID 103458 | — |
| Reactant | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| Reactant | 3-(Acetylsulfanyl)propanoyl chloride | HCID 12943122 | — |
| Reactant | 4-tert-butoxy-L-proline tertbutyl ester | HCID 54533217 | — |
| Product | 1-(3-acetylthio-1-oxopropyl)-4,5-dihydro-4-hydroxy-1H-pyrrole-2-carboxylic acid | HCID 23343191 | — |
Reaction Steps
By substituting 4-tert-butoxy-L-proline tertbutyl ester for the L-proline tert-butyl ester and 3-acetylthiopropanoyl chloride for the 3-acetylthio-2-methylpropanoyl chloride in the procedure of Example 1, 1-(3-acetylthio-1-oxopropyl)-4,5-dihydro-4-hydroxy-1H-pyrrole-2-carboxylic acid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04217458 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-a543ee68c78849d6978a9096dae03611 |
| Source note | uspto-grants-1980_08 |