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Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester → 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester | HCID 103458 | — |
| 反応物 | L-Proline | HCID 145742 | — |
| 反応物 | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| 反応物 | 4-Chloroproline | HCID 22810642 | — |
| 反応物 | Acetylthioacetylchloride | HCID 23301560 | — |
| 反応物 | 4-chloro-L-proline tertbutyl ester | HCID 57117873 | — |
| 生成物 | 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid | HCID 23343196 | — |
反応手順
By substituting 4-chloro-L-proline tertbutyl ester [prepared from 4-chloro-L-proline by the procedure described in J. Am. Chem. Soc., 82, 3359 (1960) for L-proline] for the L-proline tert-butyl ester and the 2-acetylthioacetyl chloride for the 3-acetylthio-2-methylpropanoyl chloride in the procedure of Example 1 and then submitting the product to the procedure of Example 2, 4,5-dihydro-4-chloro-1-(2-mercaptoacetyl)-1H-pyrrole-2-carboxylic acid is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04217458 |
| 出典データセット | uspto-grants-1980_08 |
| ORD ID | ord-796bbd4556974cf0b5a593295e599c76 |
| 出典メモ | uspto-grants-1980_08 |