HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester → 4,5-dihydro-1-(3-mercapto-1-oxopropyl)-4-methoxy-1H-pyrrole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanethioic acid, S-(3-chloro-2-methyl-3-oxopropyl) ester | HCID 103458 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| Reactant | 3-(Acetylsulfanyl)propanoyl chloride | HCID 12943122 | — |
| Reactant | 4-methoxy-L-proline tertbutyl ester | HCID 54187646 | — |
| Reactant | 4-methoxy-L-proline | HCID 54276716 | — |
| Product | 4,5-dihydro-1-(3-mercapto-1-oxopropyl)-4-methoxy-1H-pyrrole-2-carboxylic acid | HCID 23343193 | — |
Reaction Steps
By substituting 4-methoxy-L-proline tertbutyl ester [prepared from 4-methoxy-L-proline by the procedure described in J. Am. Chem. Soc., 82, 3359 (1960) for L-proline] for the L-proline tert-butyl ester and 3-acetylthiopropanoyl chloride for the 3-acetylthio-2-methylpropanoyl chloride in the procedure of Example 1, and then submitting the product to the procedure of Example 2, 4,5-dihydro-1-(3-mercapto-1-oxopropyl)-4-methoxy-1H-pyrrole-2-carboxylic acid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04217458 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-44a752ad038f41548514eb43d18d9765 |
| Source note | uspto-grants-1980_08 |