HCID 131711299, compound → HCID 131711298, compound

HRID 1856150Notes

Reaction equation

HRID 1856150 reaction equation
[Na+:1].[Na+].[Na+].[Na+].[Na+].[Na+].[N+:7]([C:10]1[CH:11]=[C:12]([C:51]([NH:53][C:54]2[CH:55]=[C:56]([C:61]([NH:63][C:64]3[C:73]4[C:72]([S:74]([O-:77])(=[O:76])=[O:75])=[CH:71][C:70]([S:78]([O-:81])(=[O:80])=[O:79])=[CH:69][C:68]=4[C:67]([S:82]([O-:85])(=[O:84])=[O:83])=[CH:66][CH:65]=3)=[O:62])[CH:57]=[CH:58][C:59]=2[CH3:60])=[O:52])[CH:13]=[C:14]([C:16]([NH:18][C:19]2[CH:20]=[C:21]([C:26]([NH:28][C:29]3[C:38]4[C:37]([S:39]([O-:42])(=[O:41])=[O:40])=[CH:36][C:35]([S:43]([O-:46])(=[O:45])=[O:44])=[CH:34][C:33]=4[C:32]([S:47]([O-:50])(=[O:49])=[O:48])=[CH:31][CH:30]=3)=[O:27])[CH:22]=[CH:23][C:24]=2[CH3:25])=[O:17])[CH:15]=1)([O-])=O>[Pd].O>[Na+:1].[Na+:1].[Na+:1].[Na+:1].[Na+:1].[Na+:1].[NH2:7][C:10]1[CH:11]=[C:12]([C:51]([NH:53][C:54]2[CH:55]=[C:56]([C:61]([NH:63][C:64]3[C:73]4[C:72]([S:74]([O-:77])(=[O:75])=[O:76])=[CH:71][C:70]([S:78]([O-:81])(=[O:80])=[O:79])=[CH:69][C:68]=4[C:67]([S:82]([O-:85])(=[O:84])=[O:83])=[CH:66][CH:65]=3)=[O:62])[CH:57]=[CH:58][C:59]=2[CH3:60])=[O:52])[CH:13]=[C:14]([C:16]([NH:18][C:19]2[CH:20]=[C:21]([C:26]([NH:28][C:29]3[C:38]4[C:37]([S:39]([O-:42])(=[O:40])=[O:41])=[CH:36][C:35]([S:43]([O-:46])(=[O:45])=[O:44])=[CH:34][C:33]=4[C:32]([S:47]([O-:50])(=[O:48])=[O:49])=[CH:31][CH:30]=3)=[O:27])[CH:22]=[CH:23][C:24]=2[CH3:25])=[O:17])[CH:15]=1

Participants

4

Reactant 1

HCID 131711299HCID 131711299, compound

Product 1

HCID 131711298HCID 131711298, compoundYield 536.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A mixture of 1.98 g of the product of Example 1, 60 ml of water and 500 mg of 10% palladium-on-carbon catalyst is hydrogenated in a Parr shaker. The resulting mixture is filtered, and the filtrate is evaporated. The residue is dissolved in 12 ml of hot water and 125 ml of absolute ethanol is added. The precipitate is collected, washed with ethanol and ether and dried to yield 1.73 g of the product of the Example.

Workup

  1. filtrationThe resulting mixture is filtered
  2. customthe filtrate is evaporated
  3. dissolutionThe residue is dissolved in 12 ml of hot water
  4. addition125 ml of absolute ethanol is added
  5. customThe precipitate is collected
  6. washwashed with ethanol and ether
  7. customdried

Sources & evidence

ORD record
ord-d0606d65bed244e08b1d1ed2290518b5
Source dataset
uspto-grants-1980_08
Patent number
US04218395

Reaction notes

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