2-Aminopropanediamide → HCID 178513794, compound

Participants

Reaction Steps

To a chilled solution of ethyl iminophenylacetate hydrochloride (5.99 g) in anhydrous methanol (80 ml) was added aminomalonamide (3.51 g). The mixture was stirred for 1 hour at 0°-5° C. and then 3 hours under reflux. After cooling the mixture to 0°-5° C., the precipitated product was filtered and washed with ethanol, isopropylether to give 2-benzyl-5-hydroxy-1H-imidazole-4-carboxamide (4.52 g).

Provenance & Evidence