2-Aminopropanediamide → HCID 178513785, compound

Participants

Reaction Steps

To a chilled solution of ethyl iminobenzoate hydrochloride (18.57 g) in anhydrous methanol (250 ml) was added aminomalonamide (11.71 g). The mixture was stirred for a half hour at 0°-5° C. and then 1 hour under reflux. After cooling to 0°-5° C. again, the precipitated product was filtered and washed with ethanol, isopropylether to give 2-phenyl-5-hydroxy-1H-imidazole-4-carboxamide (11.81 g).

Provenance & Evidence