Sulfuric Acid → HCID 178437680, compound

Participants

Reaction Steps

To a suspension of aminomalonamide (7.13 g) in anhydrous ethanol (240 ml) were added triethyl orthopropionate (42.93 g) and concentrated sulfuric acid (1.6 g). The reaction mixture was refluxed for 2 hours and then ice-cooled. The precipitate product was filtered and washed with ethanol, isopropylether to give 2-ethyl-5-hydroxy-1H-imidazole-4-carboxamide (6.02 g).

Provenance & Evidence