Diisopropyl Ether → HCID 178513789, compound

Participants

Reaction Steps

To a chilled suspension of 2-(4-benzoyloxyphenyl)-5-hydroxyimidazole-4-carboxamide (323 mg) in anhydrous methanol (20 ml) was added sodium methoxide (216 mg). After stirring for 5 minutes at 0°-5° C. and 15 minutes at room temperature, N-hydrochloric acid aqueous solution (4 ml) and isopropylether (30 ml) were added. The precipitated crystal was separated by filtration, washed with isopropylether and dried under vacuum to give 2-(4-hydroxyphenyl)-5-hydroxy-1H-imidazole-4-carboxamide (190 mg).

Provenance & Evidence