HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 54455049, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1-Methyl-5-nitro-1H-imidazole-2-carbaldehyde | HCID 78487 | — |
| Reactant | 1,3,4-Thiadiazole, 2-methyl-5-phenyl- | HCID 97425 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 54455049 | HCID 54455049 | 55.9% |
Reaction Steps
17.6 g of 2-methyl-5-phenyl-1,3,4-thiadiazole, 15.5 g of 1-methyl-5-nitroimidazole-2-carboxaldehyde and 0.5 g of ZnCl2 are heated in 100 ml of acetic acid and 50 ml of acetic anhydride for 7 hours at reflux temperature. After water has been added to the reaction mixture, the precipitated solid is recrystallized from glacial acetic acid. 17.5 g of a product melting at 257° C. is obtained, corresponding to 56% of the theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04218460 |
| Source dataset | uspto-grants-1980_08 |
| ORD ID | ord-4b151c84c3864758af5e4ae1bc42281a |
| Source note | uspto-grants-1980_08 |